Optimal Testosterone Levels Tied to Survival in Older Men: Higher and lower levels of testosterone (T) and its metabolites may raise mortality risk in older men, according to a study published online Nov. 20 in the Journal of Clinical Endocrinology & Metabolism.
Bu B. Yeap, MBBS, PhD, from the University of Western Australia in Perth, and colleagues studied link between T and its metabolites dihydrotestosterone (DHT) and estradiol (E2) and any cause and heart disease related death in 3,690 community-dwelling men (aged 70–89 years). Early morning samples were collected between 2001 and 2004 and data were linked to mortality through December 2010.
The researchers found that there were 974 deaths (26.4%), including 325 from heart problems . Men who died had lower baseline Testosterone dihydrotestosone and estradiol. Low testosterone was associated with all-cause mortality. There was an association between higher DHT and lower death from heart attack.
"Optimal androgen levels are a biomarker for survival because older men with midrange levels of T and DHT had the lowest death rates from any cause, whereas those with higher DHT had lower IHD mortality," the authors write.